Alexander Christy L, Miller Sarah J, Abel Steven R
School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, USA.
Ann Pharmacother. 2002 Mar;36(3):504-11. doi: 10.1345/aph.1A178.
To review available data related to the use of prostaglandin analogs (bimatoprost, latanoprost, travoprost, unoprostone) in the management of ocular hypertension and open-angle glaucoma.
Primary and review articles were identified from a MEDLINE search (1966-May 2001) and requested information from product manufacturers.
All available information, including that published in articles and abstracts, which was deemed relevant was included in this review. Limited data have been published to date.
The prostaglandin analogs appear to be effective, well-tolerated agents for the reduction of intraocular pressure (IOP) in patients with primary open-angle glaucoma and ocular hypertension. This drug class offers an alternative for patients who do not achieve control with another topical antiglaucoma agent or for those with a contraindication to first-line therapy with beta-adrenergic antagonists. Based on preliminary clinical data, bimatoprost, latanoprost, and travoprost appear to be at least as effective as timolol, while the effectiveness of unoprostone is similar or slightly less. Prostaglandin analogs may be used in conjunction with other antiglaucoma medications, although further studies must establish the optimal combination. Whether clinical experience will yield outcomes in favor of one of the prostaglandin analogs remains to be determined. Patients should be educated on adverse events associated with prostaglandin analogs, particularly the potential for changes in the pigmentation of the iris and eyelashes.
Bimatoprost, latanoprost, and travoprost appear to be equivalent to the current standard of therapy in the topical treatment of elevated IOP. Further clinical data published in article versus abstract format is required to better assess potential differences among these 3 agents.
回顾与使用前列腺素类似物（比马前列素、拉坦前列素、曲伏前列素、乌诺前列酮）治疗高眼压症和开角型青光眼相关的现有数据。
通过医学主题词表（MEDLINE）检索（1966年 - 2001年5月）确定了原始文献和综述文章，并向产品制造商索取了相关信息。
本综述纳入了所有被认为相关的可用信息，包括发表在文章和摘要中的信息。迄今为止已发表的数据有限。
前列腺素类似物似乎是降低原发性开角型青光眼和高眼压症患者眼压（IOP）的有效且耐受性良好的药物。对于使用其他局部抗青光眼药物未能控制眼压的患者或对一线β - 肾上腺素能拮抗剂治疗有禁忌证的患者，这类药物提供了一种替代选择。根据初步临床数据，比马前列素、拉坦前列素和曲伏前列素似乎至少与噻吗洛尔一样有效，而乌诺前列酮的有效性相似或略低。前列腺素类似物可与其他抗青光眼药物联合使用，不过还需进一步研究确定最佳组合。临床经验是否会得出有利于某一种前列腺素类似物的结果仍有待确定。应告知患者与前列腺素类似物相关的不良事件，特别是虹膜和睫毛色素沉着改变的可能性。
比马前列素、拉坦前列素和曲伏前列素在局部治疗眼压升高方面似乎等同于当前的治疗标准。需要更多以文章形式而非摘要形式发表的临床数据，以便更好地评估这三种药物之间的潜在差异。
