Hefle Susan L, Taylor Steve L
Food Allergy Research and Resource Program, University of Nebraska, 351 Food Industry Complex, Lincoln, NE 68583-0919, USA.
Curr Allergy Asthma Rep. 2002 Jan;2(1):63-6. doi: 10.1007/s11882-002-0041-y.
This review summarizes recent findings and controversies in the area of threshold doses for allergenic foods. Over the years, there have been many clinical reports that ingestion of small amounts of food can elicit IgE-mediated allergic reactions. In exquisitely allergic individuals, the threshold dose for elicitation of such reactions is often considered to be zero. However, some food-allergic patients report that they can tolerate small quantities of allergenic food. Are very low quantities hazardous to food-allergic consumers? How much of the offending food is too much? Why is the concept of a threshold level important? There have been very few studies to date on threshold doses for allergenic foods, and more research is needed in this important area.
本综述总结了过敏性食物阈值剂量领域的近期研究发现及争议。多年来，有许多临床报告表明，摄入少量食物可引发IgE介导的过敏反应。在过敏反应极其敏感的个体中，引发此类反应的阈值剂量通常被认为是零。然而，一些食物过敏患者报告称他们能够耐受少量的过敏性食物。极少量的过敏性食物对食物过敏的消费者是否有害？多少量的致敏食物算过量？为什么阈值水平的概念很重要？迄今为止，关于过敏性食物阈值剂量的研究很少，在这一重要领域需要更多的研究。
