Ohtera K, Zobitz M E, Luo Z P, Morrey B F, O'Driscoll S W, Ramin K D, An K-N
Orthopedic Biomechanics Laboratory, Department of Orthopedics, Mayo Clinic/Mayo Foundation, Rochester, Minnesota 55905, USA.
J Appl Physiol (1985). 2002 Apr;92(4):1494-8. doi: 10.1152/japplphysiol.00614.2001.
As there is evidence that ligamentous laxity is affected by the female hormones, we hypothesized that hormonal changes occurring during pregnancy could have a therapeutic role in preventing the development of a joint contracture. Knee joint contractures were created in pregnant and nonpregnant rats. After 2 wk of immobilization, the degree of contracture was measured with structural properties of the medial collateral and anterior cruciate ligaments and the pubic symphysis. Although not statistically significant, there was a general trend toward reduced contracture in pregnant compared with nonpregnant rats. Cutting the posterior capsule significantly decreased contracture for both the pregnant and nonpregnant groups, confirming the contribution of capsular structures to contracture. Ultimate loads of the medial collateral and anterior cruciate ligaments significantly decreased after immobilization compared with control, but there was no significant effect due to pregnancy. Stiffness and ultimate load of the pubic symphysis were not significantly different between pregnant and nonpregnant groups. The trend toward reduced contracture with pregnancy points toward a possible therapeutic role for female hormones in the prevention of postoperative and/or posttraumatic joint contracture.
由于有证据表明韧带松弛受女性激素影响，我们推测孕期发生的激素变化可能在预防关节挛缩发展方面具有治疗作用。在怀孕和未怀孕的大鼠中制造膝关节挛缩。固定2周后，通过测量内侧副韧带、前交叉韧带和耻骨联合的结构特性来评估挛缩程度。尽管无统计学意义，但与未怀孕大鼠相比，怀孕大鼠的挛缩程度总体上有减轻趋势。切断后囊显著降低了怀孕和未怀孕两组的挛缩程度，证实了囊结构对挛缩的影响。与对照组相比，固定后内侧副韧带和前交叉韧带的极限负荷显著降低，但怀孕对此无显著影响。怀孕和未怀孕组耻骨联合的刚度和极限负荷无显著差异。怀孕时挛缩减轻的趋势表明女性激素在预防术后和/或创伤后关节挛缩方面可能具有治疗作用。
