肺癌中的放射治疗和抗血管生成治疗
Radiotherapy and antiangiogenic TM in lung cancer.
作者信息
Khan Mohamed K, Miller Meredith W, Taylor Jeremy, Gill Navkiranjit K, Dick Robert D, Van Golen Kenneth, Brewer George J, Merajver Sofia D
机构信息
Department of Radiation Oncology, The University of Michigan Medical Center, Ann Arbor, MI 48109-0936, USA.
出版信息
Neoplasia. 2002 Mar-Apr;4(2):164-70. doi: 10.1038/sj.neo.7900218.
Abstract
Tetrathiomolybdate (TM) is a potent nontoxic orally delivered copper complexing agent under development for the last several years for the treatment of Wilson's disease. It has been shown to block angiogenesis in primary and metastatic tumors. Therefore, the combination of cytotoxic radiotherapy (RT) and antiangiogenic TM could target both the existing tumor and the tumor microvasculature in a comprehensive strategy. Using a Lewis lung high metastatic (LLHM) carcinoma mouse tumor model, we demonstrate that the combination of TM and RT is more effective than either used as monotherapy. We also show that their therapeutic effects are additive, with no additional toxicity. We show that TM has no significant cytotoxicity in vitro against LLHM tumor cells, further supporting the antiangiogenic mechanism for its action.
摘要
四硫代钼酸盐（TM）是一种有效的无毒口服铜络合剂，在过去几年中一直在研发用于治疗威尔逊氏病。它已被证明可阻断原发性和转移性肿瘤中的血管生成。因此，细胞毒性放疗（RT）与抗血管生成的TM联合使用，可以在一个综合策略中同时靶向现有肿瘤和肿瘤微脉管系统。使用刘易斯肺癌高转移（LLHM）癌小鼠肿瘤模型，我们证明TM与RT联合使用比单独使用任何一种疗法都更有效。我们还表明它们的治疗效果是相加的，且没有额外的毒性。我们表明TM在体外对LLHM肿瘤细胞没有明显的细胞毒性，这进一步支持了其作用的抗血管生成机制。
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