Wang Zhe, Jin Dekui, Zhou Shuaishuai, Dong Niujing, Ji Yuting, An Peng, Wang Jiaping, Luo Yongting, Luo Junjie
Department of Nutrition and Health, China Agricultural University, Beijing, China.
Department of General Practice, The Third Medical Center of Chinese PLA General Hospital, Beijing, China.
Front Oncol. 2023 Mar 23;13:1123420. doi: 10.3389/fonc.2023.1123420. eCollection 2023.
Copper is an essential micronutrient for human body and plays a vital role in various biological processes including cellular respiration and free radical detoxification. Generally, copper metabolism in the body is in a stable state, and there are specific mechanisms to regulate copper metabolism and maintain copper homeostasis. Dysregulation of copper metabolism may have a great connection with various types of diseases, such as Wilson disease causing copper overload and Menkes disease causing copper deficiency. Cancer presents high mortality rates in the world due to the unlimited proliferation potential, apoptosis escape and immune escape properties to induce organ failure. Copper is thought to have a great connection with cancer, such as elevated levels in cancer tissue and serum. Copper also affects tumor progression by affecting angiogenesis, metastasis and other processes. Notably, cuproptosis is a novel form of cell death that may provide novel targeting strategies for developing cancer therapy. Copper chelators and copper ionophores are two copper coordinating compounds for the treatment of cancer. This review will explore the relationship between copper metabolism and cancers, and clarify copper metabolism and cuproptosis for cancer targeted therapy.
铜是人体必需的微量营养素，在包括细胞呼吸和自由基解毒在内的各种生物过程中发挥着至关重要的作用。一般来说，体内的铜代谢处于稳定状态，并且存在调节铜代谢和维持铜稳态的特定机制。铜代谢失调可能与多种疾病密切相关，例如导致铜过载的威尔逊病和导致铜缺乏的门克斯病。癌症由于具有无限增殖潜能、凋亡逃逸和免疫逃逸特性从而诱发器官衰竭，在全球呈现出高死亡率。铜被认为与癌症密切相关，如在癌组织和血清中的水平升高。铜还通过影响血管生成、转移等过程来影响肿瘤进展。值得注意的是，铜死亡是一种新型细胞死亡形式，可能为开发癌症治疗提供新的靶向策略。铜螯合剂和铜离子载体是两种用于治疗癌症的铜配位化合物。本综述将探讨铜代谢与癌症之间的关系，并阐明用于癌症靶向治疗的铜代谢和铜死亡。
