Friedman Ilyse S, Shelton Ron M, Phelps Robert G
Department of Dermatology, Mount Sinai Medical Center, New York, New York 10009, USA.
Dermatol Surg. 2002 Mar;28(3):205-9. doi: 10.1046/j.1524-4725.2002.01083.x.
Minocycline-induced hyperpigmentation (MIH) is a benign condition that may persist for years despite abrogation of therapy. The Q-switched ruby laser (QSRL) has been successful in removing such lesions from the skin. To date there is no documentation of QSRL or any laser being used to treat lingual hyperpigmentation associated with minocycline therapy.
Long-term follow-up results are reported for the use of QSRL to treat lingual hyperpigmentation. The literature is reviewed comparing the use of different laser systems on MIH.
A 26-year-old woman with pigment changes of the tongue and buccal mucosa due to long-term minocycline therapy was treated with four consecutive sessions with QSRL (694 nm, 20-nsec pulse duration, and 6.5 mm spot size) at 3.6-4.0 J/cm2.
A 90% resolution was achieved after three treatments. After the final treatment the lesions were completely gone. There were no side effects reported. No new pigment was detected at follow-up.
Treatment with the QSRL is a safe and effective strategy for treating hyperpigmentation of the tongue associated with minocycline therapy.
米诺环素诱导的色素沉着（MIH）是一种良性病症，即便停止治疗也可能持续数年。调Q红宝石激光（QSRL）已成功用于去除皮肤上的此类病变。迄今为止，尚无关于使用QSRL或任何激光治疗与米诺环素治疗相关的舌部色素沉着的文献记载。
报告使用QSRL治疗舌部色素沉着的长期随访结果。回顾比较不同激光系统用于治疗MIH的文献。
一名因长期米诺环素治疗导致舌部和颊黏膜色素改变的26岁女性，接受了4次连续的QSRL治疗（波长694nm，脉冲持续时间20纳秒，光斑大小6.5mm），能量密度为3.6 - 4.0J/cm²。
三次治疗后色素沉着消退了90%。最后一次治疗后病变完全消失。未报告有副作用。随访时未发现新的色素沉着。
QSRL治疗是一种安全有效的治疗与米诺环素治疗相关的舌部色素沉着的策略。
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