Karrer S, Szeimies R M, Pfau A, Schröder J, Stolz W, Landthaler M
Dermatologische Klinik und Poliklinik, Universität Regensburg.
Hautarzt. 1998 Mar;49(3):219-23. doi: 10.1007/s001050050731.
A common adverse effect of minocycline therapy is cutaneous pigmentation. We describe two patients who presented with hyperpigmentation caused by minocycline. One patient, aged 54 years, had taken minocycline due to lung silicosis for 3 years before black pigmentation of the face occurred. The other 49 year-old patient developed grey-black hyperpigmentation on both lower legs after a 6-month therapy with minocycline for folliculitis. This patient was treated with the Q-switched ruby laser and the pigmentation resolved in the treated area. The different clinical and histological forms of minocycline-induced hyperpigmentation are discussed.
米诺环素治疗的常见不良反应是皮肤色素沉着。我们描述了两名因米诺环素导致色素沉着的患者。一名54岁的患者因肺硅沉着病服用米诺环素3年后面部出现黑色色素沉着。另一名49岁的患者在因毛囊炎接受米诺环素治疗6个月后双侧小腿出现灰黑色色素沉着。该患者接受了调Q红宝石激光治疗，治疗区域的色素沉着消失。本文讨论了米诺环素诱导色素沉着的不同临床和组织学表现形式。
