Meyerson M A, Cohen P R, Hymes S R
Department of Dermatology, University of Texas-Houston Medical School, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Feb;79(2):180-4. doi: 10.1016/s1079-2104(05)80279-3.
Minocycline can cause hyperpigmentation of the conjunctiva, oral mucosa, and skin. Pigmentation of the oral mucosa may also be associated with a variety of endogenous or exogenous factors. Lingual pigmentation may be seen in Addison's disease, amalgam tatoo, malignant melanoma, Peutz-Jegher's syndrome, and other diseases. Two women who had isolated pigmentation of the tongue while taking minocycline are described; no other drug-induced pigmentation of their oral mucosa or skin occurred. Minocycline-induced pigmentation should be added to the differential diagnosis of isolated lingual hyperpigmentation.
米诺环素可导致结膜、口腔黏膜和皮肤色素沉着。口腔黏膜色素沉着也可能与多种内源性或外源性因素有关。舌部色素沉着可见于艾迪生病、汞合金纹身、恶性黑色素瘤、黑斑息肉综合征及其他疾病。本文描述了两名在服用米诺环素时出现孤立性舌部色素沉着的女性；她们的口腔黏膜或皮肤未出现其他药物性色素沉着。米诺环素所致色素沉着应列入孤立性舌部色素沉着的鉴别诊断之中。
