Eaglstein William H, Sullivan Tory P, Giordano Philip A, Miskin Barry M
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida 33101, USA.
Dermatol Surg. 2002 Mar;28(3):263-7. doi: 10.1046/j.1524-4725.2002.01207.x.
Octyl-2-cyanoacrylate is U.S. Food and Drug Administration (FDA) approved for the closure of incisions and lacerations. In animal studies, a more flexible formulation of octyl-2-cyanoacrylate suitable for cuts and abrasions produced faster healing of partial thickness wounds than traditional bandages.
To evaluate the effectiveness of a more flexible octyl-2-cyanoacrylate liquid adhesive bandage for the treatment of minor cuts and abrasions.
One hundred sixty-two volunteers with recent minor cuts or abrasions were recruited and randomized to treatment with either liquid adhesive bandage (LAB) or a control device (Band-Aid brand adhesive bandage, sheer, 2.5 cm). The primary efficacy criterion was complete healing at day 12. Secondary efficacy criteria were the ability of patients to properly apply LAB, and the ability of LAB to stop bleeding, to reduce pain, and to remain on the wound.
At day 12 there was no statistical difference between the number of completely healed wounds in the LAB and the bandage-treated patients (P =.493). The ability of patients, as rated by investigators, to effectively apply the LAB device and the bandage was not significantly different (P =.165). Only the LAB provided significant hemostasis (P =.0001) and pain relief (P =.002).
In this randomized, controlled trial, the LAB was as effective as the control at promoting healing as measured by complete healing at day 12. The LAB was easy to use and gave rapid control of bleeding and pain, forming a film that stayed on wounds well.
2-氰基丙烯酸辛酯已获美国食品药品监督管理局（FDA）批准用于闭合切口和撕裂伤。在动物研究中，一种更适合切割伤和擦伤的柔韧性更强的2-氰基丙烯酸辛酯配方，与传统绷带相比，能使部分厚度伤口愈合得更快。
评估一种柔韧性更强的2-氰基丙烯酸辛酯液体创可贴治疗轻微切割伤和擦伤的有效性。
招募了162名近期有轻微切割伤或擦伤的志愿者，随机分为两组，分别接受液体创可贴（LAB）或对照装置（邦迪牌透明2.5厘米粘性创可贴）治疗。主要疗效标准是在第12天完全愈合。次要疗效标准包括患者正确使用LAB的能力，以及LAB止血、减轻疼痛和贴合伤口的能力。
在第12天，LAB组和绷带治疗组完全愈合的伤口数量无统计学差异（P = 0.493）。经研究者评估，患者有效使用LAB装置和绷带的能力无显著差异（P = 0.165）。只有LAB能显著止血（P = 0.0001）和减轻疼痛（P = 0.002）。
在这项随机对照试验中，以第12天的完全愈合情况衡量，LAB在促进伤口愈合方面与对照组效果相当。LAB使用方便，能迅速止血和止痛，形成的薄膜能很好地贴合伤口。
