Brozovic S, Vucicevic-Boras V, Mravak-Stipetic M, Jukic S, Kleinheinz J, Lukac J
Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Croatia.
J Oral Pathol Med. 2002 Feb;31(2):106-8. doi: 10.1034/j.1600-0714.2002.310208.x.
Vascular endothelial growth factor (VEGF) is a multifunctional angiogenic cytokine involved in angiogenesis and wound healing. Its presence in recurrent aphthous ulceration has not been reported to date. The aim of this study was to investigate the association of salivary levels of VEGF with various stages of recurrent aphthous ulceration (RAU).
VEGF levels were determined in a group of 27 age and sex-matched healthy controls and in 30 patients with minor and major RAU grouped into the three stages: (I) early active stage, (II) active stage, and (III) remission period. VEGF levels (pg/ml; mean +/- SD) in unstimulated whole saliva were determined by enzyme immunoassay.
Patients with major RAU - stages I and II - had decreased VEGF values (765 +/- 458 and 341 +/- 109, respectively) when compared both to healthy controls (1652 +/- 567; P < 0.01) and to stage III major RAU (1524 +/- 784; P < 0.005).
Salivary VEGF levels seemed to be associated with ulcer development in major RAU, showing stage-dependent alterations during the course of this disorder.
血管内皮生长因子（VEGF）是一种参与血管生成和伤口愈合的多功能血管生成细胞因子。迄今为止，尚未有其在复发性阿弗他溃疡中存在的报道。本研究的目的是调查唾液中VEGF水平与复发性阿弗他溃疡（RAU）各阶段的关联。
对27名年龄和性别匹配的健康对照者以及30名患有轻度和重度RAU的患者进行VEGF水平测定，这些患者被分为三个阶段：（I）早期活动期，（II）活动期，和（III）缓解期。通过酶免疫测定法测定未刺激的全唾液中的VEGF水平（pg/ml；平均值±标准差）。
与健康对照者（1652±567；P<0.01）以及重度RAU的III期患者（1524±784；P<0.005）相比，重度RAU的I期和II期患者的VEGF值降低（分别为765±458和341±109）。
唾液VEGF水平似乎与重度RAU中的溃疡发展相关，在该疾病过程中呈现出阶段依赖性改变。
