Mignone Flavio, Gissi Carmela, Liuni Sabino, Pesole Graziano
Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, Via Celoria, 26, 20133 Milano, Italy.
Genome Biol. 2002;3(3):REVIEWS0004. doi: 10.1186/gb-2002-3-3-reviews0004. Epub 2002 Feb 28.
Gene expression is finely regulated at the post-transcriptional level. Features of the untranslated regions of mRNAs that control their translation, degradation and localization include stem-loop structures, upstream initiation codons and open reading frames, internal ribosome entry sites and various cis-acting elements that are bound by RNA-binding proteins.
基因表达在转录后水平受到精细调控。控制mRNA翻译、降解和定位的非翻译区的特征包括茎环结构、上游起始密码子和开放阅读框、内部核糖体进入位点以及与RNA结合蛋白结合的各种顺式作用元件。
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