Kabanov Alexander V, Lemieux Pierre, Vinogradov Sergey, Alakhov Valery
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198, USA.
Adv Drug Deliv Rev. 2002 Feb 21;54(2):223-33. doi: 10.1016/s0169-409x(02)00018-2.
Pluronic block copolymers are recognized pharmaceutical excipients listed in the US and British Pharmacopoeia. They have been used extensively in a variety of pharmaceutical formulations including delivery of low molecular mass drugs and polypeptides. This review describes novel applications of Pluronic block copolymers in gene therapy. In particular, these molecules can modify the biological response during gene therapy in the skeletal muscle, resulting in an enhancement of the transgene expression as well as an enhancement of the therapeutic effect of the transgene. Furthermore, Pluronic block copolymers are versatile molecules that can be used as structural elements of the polycation-based gene delivery systems (polyplexes). Based on these studies, the use of block copolymers in gene delivery is a promising area of research, in which new and important developments are expected.
普朗尼克嵌段共聚物是美国和英国药典中列出的公认药用辅料。它们已广泛应用于各种药物制剂，包括低分子量药物和多肽的递送。这篇综述描述了普朗尼克嵌段共聚物在基因治疗中的新应用。特别是，这些分子可以在骨骼肌基因治疗过程中改变生物学反应，从而增强转基因表达以及转基因的治疗效果。此外，普朗尼克嵌段共聚物是多功能分子，可作为基于聚阳离子的基因递送系统（多聚体）的结构元件。基于这些研究，嵌段共聚物在基因递送中的应用是一个有前景的研究领域，有望取得新的重要进展。
