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聚多巴胺纳米系统在药物递送中的应用：尺寸、形态和表面电荷的影响

Polydopamine Nanosystems in Drug Delivery: Effect of Size, Morphology, and Surface Charge.

作者信息

Menichetti Arianna, Mordini Dario, Montalti Marco

机构信息

Department of Chemistry "Giacomo Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.

出版信息

Nanomaterials (Basel). 2024 Feb 1;14(3):303. doi: 10.3390/nano14030303.

DOI:10.3390/nano14030303
PMID:38334574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10856634/
Abstract

Recently, drug delivery strategies based on nanomaterials have attracted a lot of interest in different kinds of therapies because of their superior properties. Polydopamine (PDA), one of the most interesting materials in nanomedicine because of its versatility and biocompatibility, has been widely investigated in the drug delivery field. It can be easily functionalized to favor processes like cellular uptake and blood circulation, and it can also induce drug release through two kinds of stimuli: NIR light irradiation and pH. In this review, we describe PDA nanomaterials' performance on drug delivery, based on their size, morphology, and surface charge. Indeed, these characteristics strongly influence the main mechanisms involved in a drug delivery system: blood circulation, cellular uptake, drug loading, and drug release. The understanding of the connections between PDA nanosystems' properties and these phenomena is pivotal to obtain a controlled design of new nanocarriers based on the specific drug delivery applications.

摘要

近年来，基于纳米材料的药物递送策略因其卓越性能在各类治疗中引起了广泛关注。聚多巴胺（PDA）作为纳米医学中最具吸引力的材料之一，因其多功能性和生物相容性，已在药物递送领域得到广泛研究。它可以很容易地进行功能化修饰，以促进细胞摄取和血液循环等过程，还能通过近红外光照射和pH值这两种刺激诱导药物释放。在本综述中，我们基于PDA纳米材料的尺寸、形态和表面电荷，描述其在药物递送方面的性能。实际上，这些特性强烈影响药物递送系统所涉及的主要机制：血液循环、细胞摄取、药物负载和药物释放。了解PDA纳米系统的性质与这些现象之间的联系，对于基于特定药物递送应用获得新型纳米载体的可控设计至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/25b395c8ef5b/nanomaterials-14-00303-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/c7e3f97f76d3/nanomaterials-14-00303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/1d1f1fd0db7d/nanomaterials-14-00303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/71f8da7d63e2/nanomaterials-14-00303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/e2db68157cda/nanomaterials-14-00303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/cd93188da5ca/nanomaterials-14-00303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/42e2c3daaefc/nanomaterials-14-00303-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/25b395c8ef5b/nanomaterials-14-00303-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/c7e3f97f76d3/nanomaterials-14-00303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/1d1f1fd0db7d/nanomaterials-14-00303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/71f8da7d63e2/nanomaterials-14-00303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/e2db68157cda/nanomaterials-14-00303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/cd93188da5ca/nanomaterials-14-00303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/42e2c3daaefc/nanomaterials-14-00303-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb2/10856634/25b395c8ef5b/nanomaterials-14-00303-g007.jpg

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