Tomkins D M, Higgins G A, Sellers E M
Addiction Research Foundation, Toronto, Ontario, Canada.
Psychopharmacology (Berl). 1994 Jun;115(1-2):173-9. doi: 10.1007/BF02244769.
Previous work has reported that the 5-hydroxytryptamine (5-HT)1A agonist, 8-hydroxy 2-(di-n-propylamino)tetralin (8-OH DPAT), reduces ethanol intake by rats. However, as 8-OH DPAT reduces 5-HT neurotransmission, these findings are inconsistent with the proposed inhibitory role of central 5-HT neurons on ethanol intake. We examined the effect of 8-OH DPAT on ethanol, water and food intake in rats maintained on a limited access schedule using a lower dose range (6-250 micrograms/kg) and by assessing concomitant changes in behaviour. Low doses of 8-OH DPAT enhanced ethanol intake even when food and water were offered as alternatives. Suppression in ethanol intake was observed at higher doses where elements of the 5-HT syndrome were apparent. Similar observations were made in both fluid and non-fluid deprived water drinking rats, suggesting the latter effect is non-selective. Therefore 8-OH DPAT may both increase or decrease ethanol consumption in the rat depending on the dose used.
先前的研究报道，5-羟色胺（5-HT）1A激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH DPAT）可减少大鼠的乙醇摄入量。然而，由于8-OH DPAT会降低5-HT神经传递，这些发现与中枢5-HT神经元对乙醇摄入的抑制作用相悖。我们使用较低剂量范围（6-250微克/千克），并通过评估行为的伴随变化，研究了8-OH DPAT对按限时进食方案饲养的大鼠的乙醇、水和食物摄入量的影响。低剂量的8-OH DPAT即使在提供食物和水作为替代物时也会增加乙醇摄入量。在出现5-HT综合征症状的较高剂量下，观察到乙醇摄入量受到抑制。在禁水和不禁水的大鼠中都有类似的观察结果，表明后一种效应是非选择性的。因此，根据所用剂量，8-OH DPAT可能会增加或减少大鼠的乙醇消耗量。
