Palma Santiago, Luján Claudia, Llabot Juan Manuel, Barboza Gloria, Manzo Ruben Hilario, Allemandi Daniel Alberto
Departamento de Farmacia, Faculdad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria-5000, Córdoba, Argentina.
Int J Pharm. 2002 Feb 21;233(1-2):191-8. doi: 10.1016/s0378-5173(01)00940-1.
A solid pharmaceutical dosage formulation using a novel dry plant extract of Peumus boldus MOL. (Monimiaceae) (Pb) is proposed. The botanical evaluation of plant material, through morphological and anatomical diagnosis, is presented. This evaluation permits to identify the herb to be used correctly. The analysis of the most extractive solvent mixture and the attainment of plant extract (fluid and dry) are reported. Several formulations (tablets) containing a novel dry plant extract of Pb and common excipients for direct compression are evaluated. The following formulation: dry plant extract of Pb (170 mg), Avicel PH101 (112 mg), Lactose CD (112) and magnesium stearate (6 mg), compressed at 1000 mPa, showed the best pharmaceutical performance.
提出了一种使用新的波多胡椒（Peumus boldus MOL.）（番荔枝科）干燥植物提取物（Pb）的固体药物剂型。通过形态学和解剖学诊断对植物材料进行了植物学评估。该评估有助于正确识别所用的草药。报告了对最有效的提取溶剂混合物的分析以及植物提取物（液体和干燥提取物）的获得情况。对几种含有新型Pb干燥植物提取物和直接压片常用辅料的制剂（片剂）进行了评估。以下制剂：Pb干燥植物提取物（170毫克）、微晶纤维素PH101（112毫克）、乳糖CD（112毫克）和硬脂酸镁（6毫克），在1000兆帕压力下压片，显示出最佳的药物性能。
