Afaq Farrukh, Adhami Vaqar M, Ahmad Nihal, Mukhtar Hasan
Department of Dermatology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.
Front Biosci. 2002 Apr 1;7:d784-92. doi: 10.2741/afaq.
The incidence of non-melanoma skin cancer, consisting of basal- and squamous- cell carcinoma, continues to increase in the United States and elsewhere. Solar ultraviolet (UV) B radiation has been implicated as its main cause. This adverse effect of UVB has become a major human health concern. Therefore, development of novel strategies to reduce the occurrence of skin cancer is a highly desirable goal. Because UV radiation is known to cause excessive generation of reactive oxygen species (ROS) thereby resulting in an oxidative stress condition, the approaches aimed at counteracting ROS production may be useful for the prevention of skin cancer. One approach to reduce its occurrence is through 'Photochemoprotection', which we define as 'the use of agents capable of ameliorating the adverse effects of UVB on the skin'. Among many photochemoprotective agents, botanical antioxidants are showing promise. We propose that the use of botanical antioxidants, in combination with the use of sunscreens and educational efforts to avoid excessive sun exposure, may be an effective strategy for reduction of incidence of skin cancer and other UV-mediated damage in humans.
由基底细胞癌和鳞状细胞癌组成的非黑色素瘤皮肤癌的发病率在美国及其他地区持续上升。太阳紫外线（UV）B辐射被认为是其主要病因。UVB的这种不良影响已成为人类健康的一大担忧。因此，开发减少皮肤癌发生的新策略是一个非常理想的目标。由于已知紫外线辐射会导致活性氧（ROS）过度生成，从而导致氧化应激状态，旨在抵消ROS产生的方法可能对预防皮肤癌有用。减少其发生的一种方法是通过“光化学防护”，我们将其定义为“使用能够减轻UVB对皮肤不良影响的制剂”。在众多光化学防护剂中，植物抗氧化剂显示出前景。我们提出，将植物抗氧化剂与使用防晒霜以及开展避免过度日晒的教育工作相结合，可能是降低人类皮肤癌发病率和其他紫外线介导损伤的有效策略。
