Université de Bourgogne Franche-Comté, F-21000 Dijon, France.
INSERM Research Center U1231, Cancer and Adaptive Immune Response Team, Bioactive Molecules and Health Research Group, F-21000 Dijon, France.
Int J Mol Sci. 2021 Jan 28;22(3):1295. doi: 10.3390/ijms22031295.
Eye diseases are currently a major public health concern due to the growing number of cases resulting from both an aging of populations and exogenous factors linked to our lifestyles. Thus, many treatments including surgical pharmacological approaches have emerged, and special attention has been paid to prevention, where diet plays a preponderant role. Recently, potential antioxidants such as resveratrol have received much attention as potential tools against various ocular diseases. In this review, we focus on the mechanisms of resveratrol against ocular diseases, in particular age-related macular degeneration, glaucoma, cataract, diabetic retinopathy, and vitreoretinopathy. We analyze, in relation to the different steps of each disease, the resveratrol properties at multiple levels, such as cellular and molecular signaling as well as physiological effects. We show and discuss the relationship to reactive oxygen species, the regulation of inflammatory process, and how resveratrol can prevent ocular diseases through a potential epigenetic action by the activation of sirtuin-1. Lastly, various new forms of resveratrol delivery are emerging at the same time as some clinical trials are raising more questions about the future of resveratrol as a potential tool for prevention or in therapeutic strategies against ocular diseases. More preclinical studies are required to provide further insights into RSV's potential adjuvant activity.
目前，由于人口老龄化和与我们生活方式相关的外源因素导致的病例不断增加，眼部疾病成为了一个主要的公共卫生关注点。因此，许多治疗方法，包括手术和药理学方法已经出现，并且特别关注预防，其中饮食起着重要作用。最近，作为对抗各种眼部疾病的潜在工具，潜在抗氧化剂如白藜芦醇受到了广泛关注。在这篇综述中，我们重点介绍了白藜芦醇针对眼部疾病的作用机制，特别是与年龄相关的黄斑变性、青光眼、白内障、糖尿病性视网膜病变和玻璃体积血。我们分析了白藜芦醇在多种水平上的特性，例如细胞和分子信号以及生理作用，与每种疾病的不同阶段相关。我们展示并讨论了白藜芦醇与活性氧、炎症过程的调节的关系，以及白藜芦醇如何通过激活 SIRT1 发挥潜在的表观遗传作用来预防眼部疾病。最后，随着一些临床试验提出更多关于白藜芦醇作为预防或治疗眼部疾病的潜在工具的未来的问题，各种新的白藜芦醇传递形式也在不断涌现。需要更多的临床前研究来进一步深入了解 RSV 的潜在辅助活性。
