Müller K
Zentralbl Gynakol. 1975;97(15):928-35.
An information about the experience with DILATOL-treatment of 11 patients suffering from EPH-gestosis with hypertonia as the main symptom, is given. In all cases it was possible to reduce the systolic and diastolic blood-pressure. In long-time treatment an increasing resistance to therapy was noticed. In any case the treatment has to be combined with a frequent medical control of the gravidity with respect to the foetus and the placenta, to determine the right moment of the premature finishing of the gravidity, which is often necessary. Although no child of our 11 patients, died, it wasn't possible to prove the fact, that the perinatal mortality in the case of heavy EPH-gestosis after treating with beta-adrenergic substances is reduced. There weren't noticed any detrimental consequences to mother and child after treating with DILATOL within a space of time up to 4 weeks up to a total amount of 500 mg.
本文给出了11例以高血压为主要症状的妊娠高血压综合征患者使用DILATOL治疗的经验。在所有病例中，收缩压和舒张压均有可能降低。在长期治疗中，发现对治疗的耐药性增加。在任何情况下，治疗都必须结合对孕妇进行关于胎儿和胎盘的频繁医学检查，以确定早产的合适时机，这往往是必要的。尽管我们的11例患者中没有胎儿死亡，但无法证实使用β-肾上腺素能物质治疗重度妊娠高血压综合征后围产期死亡率降低这一事实。在长达4周、总量达500毫克的时间内使用DILATOL治疗后，未发现对母婴有任何不良后果。
