Mahnken A H, Tacke J, Bücker A, Günther R W
Universitätsklinikum der RWTH Aachen, Germany.
Rofo. 2002 Feb;174(2):216-23. doi: 10.1055/s-2002-20138.
To evaluate the effectiveness of a percutaneous radiofrequency ablation device, consisting of a LeVeen probe and a newly developed 200-W radiofrequency generator.
In 20 patients (9 male, 11 female), 30 primary and secondary liver malignancies were treated by CT-guided percutaneous radiofrequency ablation. The patients were separated in a potentially curable (n = 10) and a palliative (n,= 10) treatment group. The treatment was performed using an umbrella-shaped LeVeen probe with a diameter of 3.5 cm or 4 cm and a 200-W generator (Radiotherapeutics, Mountain View, CA, USA). All interventions were performed under general anesthesia by a standardized treatment protocol. The size of the lesions treated ranged from 2.2 x 2 x 2 cm to 10.8 x 10.1 x 10.5 cm.
In all patients, the correct placement of the probe and radiofrequency ablation was technically successful. In two patients more than one treatment session was necessary to achieve the intended treatment result. In all patients of the potentially curable group a complete tumor necrosis could be achieved, whereas in the palliative treatment group complete tumor necrosis was only achievable in one patient. The achieved necrosis size ranged from 2.4 x 2.8 x 2.5 cm to 9.2 x 8 x 10.5 cm. In one patient a colon fistula was observed 4 weeks after treatment. No further complications were observed. The follow-up period ranges from 1 to 15 months (mean 4.5 months).
By use of a powerful generator in combination with a LeVeen probe percutaneous treatment of even large liver tumors is possible. Radiofrequency ablation is a safe procedure for the minimal-invasive therapy of non resectable liver neoplasms.
评估一种由LeVeen探针和新开发的200瓦射频发生器组成的经皮射频消融设备的有效性。
对20例患者（9例男性，11例女性）的30处原发性和继发性肝脏恶性肿瘤进行CT引导下经皮射频消融治疗。将患者分为潜在可治愈组（n = 10）和姑息治疗组（n = 10）。使用直径为3.5 cm或4 cm的伞形LeVeen探针和200瓦发生器（美国加利福尼亚州山景城的Radiotherapeutics公司）进行治疗。所有干预措施均在全身麻醉下按照标准化治疗方案进行。所治疗病变的大小范围为2.2×2×2 cm至10.8×10.1×10.5 cm。
在所有患者中，探针的正确放置和射频消融在技术上均获成功。2例患者需要进行不止一次治疗才能达到预期治疗效果。在潜在可治愈组的所有患者中均实现了完全肿瘤坏死，而在姑息治疗组中仅1例患者实现了完全肿瘤坏死。所实现的坏死范围为2.4×2.8×2.5 cm至9.2×8×10.5 cm。1例患者在治疗后4周观察到结肠瘘。未观察到其他并发症。随访期为1至15个月（平均4.5个月）。
通过使用强大的发生器与LeVeen探针相结合，经皮治疗甚至大型肝肿瘤是可行的。射频消融是不可切除肝脏肿瘤微创治疗的一种安全方法。
