Weinstein S
Departments of Neurology and Pediatrics, George Washington University School of Medicine, Children's Hospital National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA.
Curr Neurol Neurosci Rep. 2001 Mar;1(2):155-61. doi: 10.1007/s11910-001-0011-0.
The use of electrical fields to treat epilepsy is undergoing increased scrutiny as an alternative to medications and resective surgery. Much recent attention has been focused on ionic channels and seizure control; however, nonsynaptic mechanisms may be crucial for seizure onset, raising the possibility of using electrical field application to abort seizures. Furthermore, the inhibitory effects may outlast the immediate treatment and possibly be a prophylactic intervention. This paper reviews the use of brain stimulation for treatment of epilepsy, but also cites instances where the antithetical results occur. The greatest detail focuses on disrupting the onset or shortening the seizure. The paper does not extensively review deep brain or vagal nerve stimulation.
作为药物治疗和切除性手术的替代方法，利用电场治疗癫痫正受到越来越多的审视。最近，很多注意力都集中在离子通道和癫痫控制上；然而，非突触机制可能对癫痫发作的起始至关重要，这增加了利用施加电场来终止癫痫发作的可能性。此外，抑制作用可能会在即时治疗后持续存在，并且可能是一种预防性干预措施。本文回顾了利用脑刺激治疗癫痫的情况，但也列举了出现相反结果的实例。最详细的内容集中在破坏癫痫发作的起始或缩短癫痫发作时间上。本文没有广泛回顾深部脑刺激或迷走神经刺激。
