肿瘤坏死因子受体介导的细胞凋亡的分子步骤。
Molecular steps of tumor necrosis factor receptor-mediated apoptosis.
作者信息
Gupta S
机构信息
Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine 92697, USA.
出版信息
Curr Mol Med. 2001 Jul;1(3):317-24. doi: 10.2174/1566524013363780.
Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced apoptosis. A role of RIP is emphasized and novel mechanisms of FLIP-mediated inhibition of apoptosis are discussed. In addition, various mechanisms of TNF-induced activation of mitochondrial pathway of apoptosis have been reviewed.
直到最近，人们一直认为肿瘤坏死因子（TNF）诱导的细胞凋亡完全由TNF受体I型（TNF-RI）介导，因为TNF受体II型（TNF-RII）缺乏死亡结构域。然而，已经证明TNF-RII可增强TNF-RI介导的细胞凋亡。在这篇综述中，我讨论了TNF-RII调节TNF-α诱导的细胞凋亡的证据和机制。强调了受体相互作用蛋白（RIP）的作用，并讨论了FLIP（Fas相关死亡结构域样白介素-1β转换酶抑制蛋白）介导的细胞凋亡抑制的新机制。此外，还综述了TNF诱导的细胞凋亡线粒体途径激活的各种机制。
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