Källskog O, Lindbom L O, Ulfendahl H R, Wolgast M
Acta Physiol Scand. 1975 Nov;95(3):293-300. doi: 10.1111/j.1748-1716.1975.tb10053.x.
The quantitative relation between the driving forces over the glomerular membrane and the glomerular plasma flow, on the one hand, and the single glomerular filtration rate (SNGFR), on the other, is still uncertain. Micropuncture measurements on Sprague-Dawley rats made it possible to calculate the net driving force over the glomerular membrane. The single glomerular plasma flow was determined from SNGFR and the single nephron filtration fraction (SNFF). The effective plasma flow was measured with PAH for total kidney and for superficial nephrons. The mean glomerular capillary pressure was found to be 62.6 mm Hg. The results indicate a net driving force of about 13 mm Hg at the distal end of the glomerular capillary. SNGFR was found to be 14.1 nl/min-100 g. SNFF amounted to about 0.27. The filtration fractions determined with the PAH method were in the same range. The results indicate a filtration disequilibrium, in contrast to those of Brenner et al. from measurements on a mutant Wistar rat strain. The filtration fractions seemed to be the same in all glomerular populations. It is clear that the SNGFR is pressure dependent. Our earlier findings of a nonautoregulation of the blood flow through the outer glomeruli were also confirmed.
一方面，肾小球膜上的驱动力与肾小球血浆流量之间，另一方面，与单个肾小球滤过率（SNGFR）之间的定量关系仍不明确。对斯普拉格 - 道利大鼠进行的微穿刺测量使得计算肾小球膜上的净驱动力成为可能。单个肾小球血浆流量由SNGFR和单个肾单位滤过分数（SNFF）确定。用对氨基马尿酸（PAH）测量了全肾和浅表肾单位的有效血浆流量。发现平均肾小球毛细血管压力为62.6毫米汞柱。结果表明在肾小球毛细血管远端的净驱动力约为13毫米汞柱。发现SNGFR为14.1纳升/分钟 - 100克。SNFF约为0.27。用PAH方法测定的滤过分数在相同范围内。与布伦纳等人对一种突变的Wistar大鼠品系测量的结果相反，这些结果表明存在滤过不平衡。在所有肾小球群体中滤过分数似乎相同。显然，SNGFR依赖于压力。我们早期关于通过外肾小球的血流不存在自身调节的发现也得到了证实。
