Ogurtsov Pavel P., Garmash Irina V., Miandina Galina I., Guschin Alexander E., Itkes Alexander V., Moiseev Valentin S.
Peoples Friendship University of Russia, School of Medicine, Moscow; Research Institute of Addictions, Department of Toxicology, Moscow, Russia.
Addict Biol. 2001 Sep;6(4):377-383. doi: 10.1080/13556210020077109.
The frequency ADH2-2 allele in the Moscow urban population and a correlation between the ADH2-2 allele, alcoholic dependence without cirrhosis, symptomatic alcoholic cirrhosis and status on hepatitis B and C infection have been studied. One hundred and twenty-three inhabitants of Moscow (50 healthy donors, 36 patients with alcoholic cirrhosis (subdivided into infected and uninfected by HBV and/or HCV) and 37 patients with alcoholic dependence) of a similar age/sex and drinking pattern have been analysed. The frequency of 41% for ADH2-2 allele is characteristic for an urban Moscow population. This value is intermediate between that found for Asian peoples and for Central and Western Europe. There is a negative correlation between the ADH2-2 allele and alcohol misuse (both alcoholic dependence and alcoholic cirrhosis). This correlation is expressed more in alcoholic dependence. In spite of the possession of the ADH2-2 allele (or genotype ADH2-1/2), alcohol misuse increases the risk of cirrhosis. At the same time, positive status for active hepatitis B, C or combined infection B + C (replication markers HBV-DNA or HCV-RNA) increases the risk for symptomatic alcoholic cirrhosis in alcohol abusing patients, independently of ADH2 genotype.
研究了莫斯科城市人群中ADH2 - 2等位基因的频率，以及ADH2 - 2等位基因与无肝硬化的酒精依赖、有症状的酒精性肝硬化以及乙型和丙型肝炎感染状况之间的相关性。分析了123名年龄/性别和饮酒模式相似的莫斯科居民（50名健康献血者、36名酒精性肝硬化患者（分为HBV和/或HCV感染组和未感染组）以及37名酒精依赖患者）。ADH2 - 2等位基因频率为41%是莫斯科城市人群的特征。该值介于亚洲人群和中欧及西欧人群的值之间。ADH2 - 2等位基因与酒精滥用（酒精依赖和酒精性肝硬化）之间存在负相关。这种相关性在酒精依赖中表现得更为明显。尽管拥有ADH2 - 2等位基因（或基因型ADH2 - 1/2），酒精滥用仍会增加肝硬化的风险。同时，活动性乙型肝炎、丙型肝炎或合并感染B + C（复制标志物HBV - DNA或HCV - RNA）呈阳性状态会增加酗酒患者出现有症状酒精性肝硬化的风险，且与ADH2基因型无关。
