Li Hui, Mukherjee Namita, Soundararajan Usha, Tarnok Zsanett, Barta Csaba, Khaliq Shagufta, Mohyuddin Aisha, Kajuna Sylvester L B, Mehdi S Qasim, Kidd Judith R, Kidd Kenneth K
Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Am J Hum Genet. 2007 Oct;81(4):842-6. doi: 10.1086/521201. Epub 2007 Aug 24.
The ADH1B Arg47His polymorphism has been convincingly associated with alcoholism in numerous studies of several populations in Asia and Europe. In a review of literature from the past 30 years, we have identified studies that report allele frequencies of this polymorphism for 131 population samples from many different parts of the world. The derived ADH1B*47His allele reaches high frequencies only in western and eastern Asia. To pursue this pattern, we report here new frequency data for 37 populations. Most of our data are from South and Southeast Asia and confirm that there is a low frequency of this allele in the region between eastern and western Asia. The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia.
乙醇脱氢酶1B（ADH1B）基因的Arg47His多态性在亚洲和欧洲多个群体的大量研究中已被确凿地证明与酒精中毒有关。在对过去30年文献的回顾中，我们找到了一些研究，这些研究报告了来自世界许多不同地区的131个群体样本中该多态性的等位基因频率。衍生的ADH1B*47His等位基因仅在西亚和东亚达到高频率。为了探究这种模式，我们在此报告37个群体的新频率数据。我们的大部分数据来自南亚和东南亚，证实了在西亚和东亚之间的地区该等位基因频率较低。这种分布表明，在人类遍布欧亚大陆之后，衍生等位基因在西亚和东亚独立地增加了频率。
