Hulshoff Pol Hilleke E, Hijman Ron, Tulleken Cornelis A F, Heeren Thea J, Schneider Nico, van Ree Jan M
Department of Psychiatry A01.126, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Neuropsychologia. 2002;40(7):888-91. doi: 10.1016/s0028-3932(01)00167-1.
The involvement of the frontal cortex and thalamic nucleus in odor discrimination in humans was assessed. Six patients with frontal lobe brain damage, seven patients with alcoholic Korsakoff's syndrome and 16 healthy comparison subjects completed odor detection and odor discrimination tasks. Multivariate general linear modeling with age as a covariant revealed significantly decreased odor discrimination ability in frontal lobe damaged patients and marginally decreased odor discrimination ability in Korsakoff's syndrome patients as compared to the healthy comparison subjects. No deficits were found in odor detection ability. The findings suggest that in human odor discrimination, there is more involvement of cortico-cortical pathways than of thalamo-cortical pathways.
评估了额叶皮质和丘脑核在人类气味辨别中的参与情况。六名额叶脑损伤患者、七名酒精性柯萨科夫综合征患者和16名健康对照受试者完成了气味检测和气味辨别任务。以年龄为协变量的多变量一般线性模型显示，与健康对照受试者相比，额叶受损患者的气味辨别能力显著下降，柯萨科夫综合征患者的气味辨别能力略有下降。在气味检测能力方面未发现缺陷。研究结果表明，在人类气味辨别中，皮质-皮质通路比丘脑-皮质通路的参与度更高。
