Jones Dawn E, Rowland Marie, Bracewell R Martyn
School of Psychology, Bangor University, Brigantia Building, Penrallt Road, Bangor, Gwynedd LL57 2AS, UK.
ISRN Otolaryngol. 2011 Oct 15;2011:506167. doi: 10.5402/2011/506167. Print 2011.
Whilst olfactory dysfunction has been reported in Korsakoff's Syndrome (KS) patients, the diagnostic implications of this have not been fully explored. KS can be difficult to diagnose because cognitive symptoms are similar to other diagnoses. For instance, patients with Frontal Lobe (FL) Syndrome may present with memory impairments that are similar to KS. Participants were given the Benton Visual Retention Test-Fifth Edition (BVRT-V), to identify working memory dysfunction, and a Brief Smell Identification Test (B-SIT), to evaluate olfactory function. B-SIT scores were found to be significantly lower in the KS group compared to the control and FL groups. In contrast, the error scores on the BVRT-V were significantly higher in both the KS and FL groups compared to the healthy control subjects. Therefore, we suggest that olfactory function may aid in the differential diagnosis of patients presenting with working memory dysfunction.
虽然已有报道称柯萨科夫综合征（KS）患者存在嗅觉功能障碍，但对此的诊断意义尚未得到充分探索。KS可能难以诊断，因为其认知症状与其他病症相似。例如，额叶（FL）综合征患者可能出现与KS相似的记忆障碍。研究参与者接受了本顿视觉保持测验第五版（BVRT-V）以识别工作记忆功能障碍，以及简易嗅觉识别测试（B-SIT）以评估嗅觉功能。结果发现，与对照组和FL组相比，KS组的B-SIT得分显著更低。相反，与健康对照受试者相比，KS组和FL组的BVRT-V错误得分均显著更高。因此，我们认为嗅觉功能可能有助于对存在工作记忆功能障碍的患者进行鉴别诊断。
