Lederman Robert J, Guttman Michael A, Peters Dana C, Thompson Richard B, Sorger Jonathan M, Dick Alexander J, Raman Venkatesh K, McVeigh Elliot R
Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Md 20892-1061, USA.
Circulation. 2002 Mar 19;105(11):1282-4. doi: 10.1161/01.cir.0000012425.71261.fc.
We tested the feasibility of targeted left ventricular (LV) mural injection using real-time MRI (rtMRI).
A 1.5T MRI scanner was customized with a fast reconstruction engine, transfemoral guiding catheter-receiver coil (GCC), MRI-compatible needle, and tableside consoles. Commercial real-time imaging software was customized to facilitate catheter navigation and visualization of injections at 4 completely refreshed frames per second. The aorta was traversed and the left ventricular cavity was entered under direct rtMRI guidance. Pigs underwent multiple injections with dilute gadolinium-DTPA. All myocardial segments were readily accessed. The active GCC and the passive Stiletto needle injector were readily visualized. More than 50 endomyocardial injections were performed with the aid of rtMRI; 81% were successful with this first-generation prototype.
Percutaneous endomyocardial drug delivery is feasible with the aid of rtMRI, which permits precise 3-dimensional localization of injection within the LV wall.
我们测试了使用实时磁共振成像（rtMRI）进行靶向左心室（LV）壁注射的可行性。
一台1.5T磁共振成像扫描仪配备了快速重建引擎、经股引导导管-接收线圈（GCC）、磁共振成像兼容针和床边控制台。定制了商业实时成像软件，以促进导管导航并以每秒4帧的完全刷新速度可视化注射过程。在直接rtMRI引导下穿过主动脉并进入左心室腔。对猪进行多次稀释钆-DTPA注射。所有心肌节段均易于到达。活性GCC和被动式细针注射器易于可视化。借助rtMRI进行了50多次心内膜下注射；第一代原型的成功率为81%。
借助rtMRI进行经皮心内膜给药是可行的，rtMRI可实现LV壁内注射的精确三维定位。
