Kao Chen-Hung, Zeng Zhao-Bang
Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan, Republic of China.
Genetics. 2002 Mar;160(3):1243-61. doi: 10.1093/genetics/160.3.1243.
We use the orthogonal contrast scales proposed by Cockerham to construct a genetic model, called Cockerham's model, for studying epistasis between genes. The properties of Cockerham's model in modeling and mapping epistatic genes under linkage equilibrium and disequilibrium are investigated and discussed. Because of its orthogonal property, Cockerham's model has several advantages in partitioning genetic variance into components, interpreting and estimating gene effects, and application to quantitative trait loci (QTL) mapping when compared to other models, and thus it can facilitate the study of epistasis between genes and be readily used in QTL mapping. The issues of QTL mapping with epistasis are also addressed. Real and simulated examples are used to illustrate Cockerham's model, compare different models, and map for epistatic QTL. Finally, we extend Cockerham's model to multiple loci and discuss its applications to QTL mapping.
我们使用科克伦提出的正交对比量表构建了一个遗传模型，称为科克伦模型，用于研究基因间的上位性。研究并讨论了科克伦模型在连锁平衡和不平衡状态下对上位性基因进行建模和定位的特性。由于其正交特性，与其他模型相比，科克伦模型在将遗传方差划分为各个组成部分、解释和估计基因效应以及应用于数量性状基因座（QTL）定位方面具有多个优势，因此它有助于基因间上位性的研究，并能方便地用于QTL定位。还讨论了存在上位性时QTL定位的问题。使用实际例子和模拟例子来说明科克伦模型、比较不同模型以及定位上位性QTL。最后，我们将科克伦模型扩展到多个基因座，并讨论其在QTL定位中的应用。
