吉西他滨相关的肺部毒性。
Gemcitabine-related pulmonary toxicity.
作者信息
Joerger M, Gunz A, Speich R, Pestalozzi Bernhard C
机构信息
Department of Internal Medicine, Division of Oncology, University Hospital, Rämistrasse 100, CH-8091 Zurich, Switzerland.
出版信息
Swiss Med Wkly. 2002 Jan 12;132(1-2):17-20. doi: 10.4414/smw.2002.09893.
BACKGROUND
Gemcitabine is an increasingly used and generally well tolerated anticancer drug. Rarely, it leads to potentially fatal pulmonary toxicity.
CASE DESCRIPTIONS AND RESULTS
We describe the clinical features of 5 patients with gemcitabine-related pulmonary toxicity. Due to early diagnosis, prompt discontinuation of the drug, and treatment with steroids, toxicity was reversible in all cases.
CONCLUSION
Early recognition of gemcitabine-related pulmonary toxicity is mandatory.
背景
吉西他滨是一种使用越来越广泛且总体耐受性良好的抗癌药物。它极少会导致潜在致命的肺部毒性。
病例描述与结果
我们描述了5例吉西他滨相关肺部毒性患者的临床特征。由于早期诊断、及时停药以及使用类固醇治疗，所有病例的毒性均可逆。
结论
必须早期识别吉西他滨相关的肺部毒性。
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