Oncology Service, A Coruña University Hospital, A Coruña, Spain.
Clin Transl Oncol. 2010 Jun;12(6):450-2. doi: 10.1007/s12094-010-0533-5.
Gemcitabine is indicated for the treatment of nonmicrocytic lung, breast, pancreatic, bladder and ovarian cancer. Mild dyspnea has been reported but the incidence of severe lung damage is low. We report the case of a 58-year-old woman diagnosed with locally advanced infiltrating ductal carcinoma of the breast who received gemcitabine as part of neoadjuvant chemotherapy and suffered from severe pulmonary toxicity. We reviewed the cases published in the literature and conclude that although Gemcitabine is generally well tolerated, pulmonary toxicity requires high level of suspicion and prompt treatment to prevent an unfavourable outcome.
吉西他滨用于治疗非小细胞肺癌、乳腺癌、胰腺癌、膀胱癌和卵巢癌。有报道称会出现轻度呼吸困难，但严重肺损伤的发生率较低。我们报告了一例 58 岁女性浸润性导管癌局部晚期患者，接受吉西他滨作为新辅助化疗的一部分，发生严重肺毒性。我们回顾了文献中的病例，并得出结论，尽管吉西他滨通常具有良好的耐受性，但肺毒性需要高度怀疑，并及时治疗，以防止不良后果。
