Ross J S, Cohen M B
Department of Pathology and Laboratory Medicine, Albany Medical College, New Scotland Avenue, Albany, New York 12208, USA.
Expert Rev Mol Diagn. 2001 May;1(1):39-52. doi: 10.1586/14737159.1.1.39.
In this review, a series of biomarkers and molecular assays are compared with conventional urothelial cytology in their ability to detect recurrent bladder cancer. The tests considered in detail include the BTA test, NMP 22 test, DNA ploidy measurements, telomerase determinations and microsatellite instability assays. Although all of these measurements show some degree of improvement for cancer detection, the microsatellite instability assay shows the highest sensitivity and specificity. Additional biomarkers considered in the review include bladder cancer tumor antigens, growth factors, cell adhesion molecules and various molecular markers including cell cycle regulatory genes and p53 mutations.
在本综述中，将一系列生物标志物和分子检测方法与传统尿路上皮细胞学在检测复发性膀胱癌的能力方面进行了比较。详细考虑的检测包括膀胱肿瘤抗原检测（BTA检测）、核基质蛋白22检测（NMP 22检测）、DNA倍体测量、端粒酶测定和微卫星不稳定性检测。尽管所有这些检测在癌症检测方面都有一定程度的改进，但微卫星不稳定性检测显示出最高的敏感性和特异性。该综述中考虑的其他生物标志物包括膀胱癌肿瘤抗原、生长因子、细胞粘附分子以及各种分子标志物，包括细胞周期调控基因和p53突变。
