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在社区临床试验中实现最大保留率

Maximizing retention in community-based clinical trials.

作者信息

Davis Linda Lindsey, Broome Marion E, Cox Ruth P

机构信息

Room 410, School of Nursing, 1701 University Blvd., University of Alabama at Birmingham, Birmingham, AL 35294-1210, USA.

出版信息

J Nurs Scholarsh. 2002;34(1):47-53. doi: 10.1111/j.1547-5069.2002.00047.x.

DOI:10.1111/j.1547-5069.2002.00047.x
PMID:11901967
Abstract

PURPOSE

To identify and discuss retention strategies and their effectiveness in community-based clinical trials in the last decade.

METHODS

Online and hand searches for reports for the period 1990-1999. A total of 87 reports on 64 different trials were found; 21 of these published reports included a description of both retention strategies and outcomes. These studies, rank-ordered on participant retention, were compared.

FINDINGS

Despite differences in study populations, interventions, and endpoints, community-based trials with the highest retention rates included a combination of retention strategies.

CONCLUSIONS

As more funding agencies emphasize clinical trials, more investigators will be held accountable for credible and generalizable findings based on retaining the projected number of study participants. The small number of published reports for the decade that identified both retention strategies and outcomes substantiates the need to better document these factors in future research reports.

摘要

目的

识别并讨论过去十年基于社区的临床试验中的保留策略及其有效性。

方法

通过在线和手工检索1990 - 1999年期间的报告。共找到87份关于64项不同试验的报告;其中21份已发表报告包含了保留策略和结果的描述。对这些根据参与者保留率进行排序的研究进行了比较。

结果

尽管研究人群、干预措施和终点存在差异,但保留率最高的基于社区的试验采用了多种保留策略。

结论

随着越来越多的资助机构强调临床试验,更多的研究者将因基于保留预期数量的研究参与者得出可信且可推广的结果而承担责任。该十年中同时确定了保留策略和结果的已发表报告数量较少,这证实了在未来研究报告中更好地记录这些因素的必要性。

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