Duggirala R, Williams J T, Williams-Blangero S, Blangero J
Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio.
Genet Epidemiol. 1997;14(6):987-92. doi: 10.1002/(SICI)1098-2272(1997)14:6<987::AID-GEPI71>3.0.CO;2-G.
We developed and utilized a multipoint variance components method to test for linkage between a disease trait and markers on chromosome 5 in the simulated data provided in GAW10 Problem 2. We demonstrated that the discrete trait variance components method recovers unbiased estimates of quantitative trait locus (QTL) location and reasonable estimates of effect size. We also showed that dichotomization of (a continuous trait such as) Q1 diminished the power to detect linkage compared to direct analysis of Q1, and that extended pedigree analyses provided superior power to detect linkage compared to those in nuclear families.
我们开发并运用了一种多点方差分量法，以检测GAW10问题2中提供的模拟数据里疾病性状与5号染色体上标记之间的连锁关系。我们证明，离散性状方差分量法能够获得数量性状位点（QTL）位置的无偏估计以及效应大小的合理估计。我们还表明，与直接分析Q1相比，对（如）Q1这样的连续性状进行二分法会降低检测连锁的效能，并且与核心家系相比，扩展家系分析在检测连锁方面具有更高的效能。
