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蛙皮素对人体胃外胃泌素的作用。

Effect of bombesin on extragastric gastrin in man.

作者信息

Basso N, Lezoche E, Materia A, Giri S, Speranza V

出版信息

Am J Dig Dis. 1975 Oct;20(10):923-7. doi: 10.1007/BF01070877.

DOI:10.1007/BF01070877
PMID:1190200
Abstract

The effect of a protein test meal and a bombesin infusion on extragastric gastrin levels was studied in patients with truncal vagotomy, antrectomy, and gastroduodenostomy or gastrojejunostomy and in patients with total gastrectomy. In patients with vagotomy, antrectomy, and gastroduodenostomy and in patients with total gastrectomy the gastrin levels were raised by 33% and 35%, respectively, from basal after test meal, while during BBS infusion gastrin values decreased by 25% and 30%, respectively, from basal. In patients with vagotomy, antrectomy, and gastrojejunostomy, test meal and BBS infusion did not significantly alter basal gastrin values. It is concluded that BBS does not stimulate extragastric gastrin.

摘要

在接受了迷走神经切断术、胃窦切除术和胃十二指肠吻合术或胃肠吻合术的患者以及接受了全胃切除术的患者中,研究了蛋白质测试餐和蛙皮素输注对胃外胃泌素水平的影响。在接受迷走神经切断术、胃窦切除术和胃十二指肠吻合术的患者以及接受全胃切除术的患者中,测试餐后胃泌素水平分别比基础水平升高了33%和35%,而在输注蛙皮素期间,胃泌素值分别比基础水平降低了25%和30%。在接受迷走神经切断术、胃窦切除术和胃肠吻合术的患者中,测试餐和蛙皮素输注并未显著改变基础胃泌素值。得出的结论是,蛙皮素不会刺激胃外胃泌素。

相似文献

1
Effect of bombesin on extragastric gastrin in man.蛙皮素对人体胃外胃泌素的作用。
Am J Dig Dis. 1975 Oct;20(10):923-7. doi: 10.1007/BF01070877.
2
Effects of truncal vagotomy and antrectomy on bombesin-stimulated pancreatic secretion, release of gastrin, and pancreatic polypeptide in the anesthetized dog.迷走神经干切断术和胃窦切除术对麻醉犬中蛙皮素刺激的胰腺分泌、胃泌素释放及胰多肽的影响。
Dig Dis Sci. 1981 Oct;26(10):871-7. doi: 10.1007/BF01309489.
3
Evidence that bombesin releases extragastric gastrin in man.
Regul Pept. 1985 May;11(1):43-9. doi: 10.1016/0167-0115(85)90030-8.
4
Acid and gastrin levels after bombesin and calcium infusion in patients with incomplete antrectomy.胃窦部分切除术后患者注射蛙皮素和钙剂后胃酸及胃泌素水平
Am J Dig Dis. 1977 Feb;22(2):125-8. doi: 10.1007/BF01072954.
5
Studies of the release of gastrin from the human duodenum induced by gastrin-releasing peptide.关于胃泌素释放肽诱导人十二指肠释放胃泌素的研究。
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6
Effect of antrectomy and subsequent vagotomy on the serum gastrin response to food in dogs.胃窦切除术及随后的迷走神经切断术对犬血清胃泌素对食物反应的影响。
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7
Effects of bombesin and calcium on serum gastrin levels in patients with retained or excluded antral mucosa.蛙皮素和钙对保留或排除胃窦黏膜患者血清胃泌素水平的影响。
Adv Exp Med Biol. 1978;106:319-24. doi: 10.1007/978-1-4684-7248-6_40.
8
Gastrin release after truncal vagotomy in fistula dogs: hypersensitivity to bombesin but not bethanechol.瘘管犬行迷走神经干切断术后胃泌素的释放:对蛙皮素敏感但对氨甲酰甲胆碱不敏感。
Peptides. 1980 Fall;1(3):217-22. doi: 10.1016/0196-9781(80)90057-1.
9
Increase in duodenal tissue gastrin in dogs following antrectomy with gastroduodenostomy and after total gastrectomy with oesophagoduodenostomy.行胃十二指肠吻合术的胃窦切除术后以及行食管十二指肠吻合术的全胃切除术后犬十二指肠组织胃泌素的增加。
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10
The role of gastrointestinal peptides on pancreatic secretion in response to different stimulants in conscious rats.胃肠肽在清醒大鼠中对不同刺激物的胰腺分泌反应中的作用。
Int J Pancreatol. 1993 Dec;14(3):245-52. doi: 10.1007/BF02784933.

引用本文的文献

1
Changes of Gastric Secretion after Bolus and Slow Intravenous Administration of Bombesin and Neurotensin.静脉推注和缓慢静脉注射蛙皮素与神经降压素后胃分泌的变化
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2
Effects of truncal vagotomy and antrectomy on bombesin-stimulated pancreatic secretion, release of gastrin, and pancreatic polypeptide in the anesthetized dog.迷走神经干切断术和胃窦切除术对麻醉犬中蛙皮素刺激的胰腺分泌、胃泌素释放及胰多肽的影响。
Dig Dis Sci. 1981 Oct;26(10):871-7. doi: 10.1007/BF01309489.
3
Origin of gastrin liberated by gastrin releasing peptide in man.

本文引用的文献

1
Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes.铃蟾肽和产婆蟾肽的分离与结构,这两种来自欧洲两栖动物铃蟾属和产婆蟾属皮肤的类似活性肽。
Experientia. 1971 Feb 15;27(2):166-7. doi: 10.1007/BF02145873.
2
Determination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay.血清胃泌素的测定。放射免疫分析法可靠性的评估。
Scand J Gastroenterol. 1973;8(2):101-12.
3
Gastrin release in postoperative ulcer patients: evidence for release of duodenal gastrin.
胃泌素释放肽在人体内释放的胃泌素的来源。
Gut. 1987 Sep;28(9):1128-33. doi: 10.1136/gut.28.9.1128.
4
Gastrin cell function in familial multiple endocrine neoplasia type I.I型家族性多发性内分泌腺瘤病中的胃泌素细胞功能
Gut. 1988 Oct;29(10):1358-63. doi: 10.1136/gut.29.10.1358.
5
Acid and gastrin levels after bombesin and calcium infusion in patients with incomplete antrectomy.胃窦部分切除术后患者注射蛙皮素和钙剂后胃酸及胃泌素水平
Am J Dig Dis. 1977 Feb;22(2):125-8. doi: 10.1007/BF01072954.
6
Studies with bombesin in man.
World J Surg. 1979 Sep 20;3(5):579-85. doi: 10.1007/BF01654763.
术后溃疡患者的胃泌素释放:十二指肠胃泌素释放的证据
Gastroenterology. 1973 Mar;64(3):363-9.
4
Gastrin release by bombesin in the dog.蛙皮素在犬体内引起胃泌素释放。
Br J Pharmacol. 1974 Oct;52(2):219-25. doi: 10.1111/j.1476-5381.1974.tb09703.x.
5
Production and evaluation of antibodies for the radioimmunoassay of gastrin.用于胃泌素放射免疫测定的抗体的制备与评估。
Scand J Clin Lab Invest. 1972 Oct;30(2):221-32. doi: 10.3109/00365517209081114.
6
External pancreatic secretion after bombesin infusion in man.人体输注蛙皮素后的胰腺外分泌
Gut. 1975 Dec;16(12):994-8. doi: 10.1136/gut.16.12.994.