Baun D C, Bowen B M, Wood D E
Am J Hosp Pharm. 1975 Oct;32(10):1047-9.
Comparative in vivo absorption of cyanocobalamin from two dosage forms, gelatin capsule and liquid, was studied. Forty-two subjects received simultaneous doses of cyanocobalamin in capsule and liquid form, labeled with cobalt-57 and cobalt-60, respectively. Excretion, a measure of absorption, was between 2 percent and 66 percent greater with the liquid form. In vitro dissolution studies showed that the capsules had a tendency to collapse into a stringy mass and to dissolve slowly.
研究了两种剂型（明胶胶囊和液体剂型）的钴胺素在体内的吸收情况比较。42名受试者同时分别服用了用钴 - 57和钴 - 60标记的胶囊剂型和液体剂型的钴胺素。作为吸收指标的排泄量，液体剂型比胶囊剂型高2%至66%。体外溶出度研究表明，胶囊有塌缩成丝状团块并缓慢溶解的趋势。
