Dellino Gaetano I, Tatout Christophe, Pirrotta Vincenzo
Department of Zoology, University of Geneva, Switzerland.
Int J Dev Biol. 2002 Jan;46(1):133-41.
The Polycomb Response Element (PRE) is the nucleation site for the Polycomb silencing complexes. The sequences responsible for the recruitment of the components of the Polycomb complex are not well understood. A comparison of the bxd PRE sequences from several different Drosophila species shows that some changes have occurred during phylogeny but large blocks of sequence are conserved after a divergence of some 60 million years. We compare the PRE sequences, the sites of some known PRE binding proteins, the conservation of DNasel hypersensitive sites and relate them to the sequence of the Ultrabithorax promoter which these PREs regulate.
多梳反应元件（PRE）是多梳沉默复合体的成核位点。负责招募多梳复合体组分的序列尚未完全明确。对几种不同果蝇物种的bxd PRE序列进行比较后发现，在系统发育过程中发生了一些变化，但经过约6000万年的分化后，大片段序列仍保持保守。我们比较了PRE序列、一些已知PRE结合蛋白的位点、DNase I超敏位点的保守性，并将它们与这些PRE所调控的超双胸基因启动子的序列相关联。
