Lauffart Brenda, Howell Scott J, Tasch Jason E, Cowell John K, Still Ivan H
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
Biochem J. 2002 Apr 1;363(Pt 1):195-200. doi: 10.1042/0264-6021:3630195.
Dysregulation of the human transforming acidic coiled-coil (TACC) proteins is thought to be important in the evolution of breast cancer and multiple myeloma. However, the exact role of these proteins in the oncogenic process is currently unknown. Using the full-length TACC1 protein as bait to screen a human mammary epithelial cDNA library, we have identified two genes that are also amplified and overexpressed in tumours derived from different cellular origins. TACC1 interacts with the C-terminus of both the microtubule-associated colonic and hepatic tumour overexpressed (ch-TOG) protein, and the oncogenic transcription factor glioma amplified sequence 41/NuMA binding protein 1 (GAS41/NuBI1; where NuMA stands for nuclear mitotic apparatus protein 1). This suggests that the TACC proteins can form multiple complexes, dysregulation of which may be an important step during tumorigenesis.
人类转化酸性卷曲螺旋（TACC）蛋白的失调被认为在乳腺癌和多发性骨髓瘤的发生发展中起重要作用。然而，这些蛋白在致癌过程中的确切作用目前尚不清楚。我们以全长TACC1蛋白为诱饵筛选人乳腺上皮cDNA文库，鉴定出两个在源自不同细胞起源的肿瘤中也发生扩增和过表达的基因。TACC1与微管相关的结肠和肝肿瘤过表达（ch-TOG）蛋白的C末端以及致癌转录因子神经胶质瘤扩增序列41/核有丝分裂器蛋白1结合蛋白1（GAS41/NuBI1；其中NuMA代表核有丝分裂器蛋白1）相互作用。这表明TACC蛋白可以形成多种复合物，其失调可能是肿瘤发生过程中的一个重要步骤。
