Kayarkar R, Clifton N J, Woolford T J
Department of Otorhinolaryngology, Royal Hallamshire Hospital, Sheffield, UK.
Clin Otolaryngol Allied Sci. 2002 Feb;27(1):18-21. doi: 10.1046/j.1365-2273.2002.00515.x.
Steroid nose drops are used frequently to treat rhinosinusitis and nasal polyposis. The middle meatal area is of key importance in the pathophysiology of these conditions. This study assesses which of three head positions commonly used to instil nose drops resulted in the highest coverage of this area. Discomfort levels were also studied using a visual analogue scale for each position. Five volunteers were studied in: (i) head back (HB); (ii) head forward and down (HFD); and (iii) lying head back (LHB) positions. Betamethasone nose drops, dyed with fluorescein, were instilled into each nostril and the distribution was studied endoscopically. The middle meatus area distribution was highest in the LHB position (55.51%), followed by HFD (31.55%) and HB (6.87%) positions. Comparison of distribution between HB and LHB (P = 0.002) and between HB and HFD (P = 0.045) was statistically significant. The HFD position was most uncomfortable (mean discomfort score 8.8) whereas the HB (2.4) and LHB (2.6) were similar. The LHB would, therefore, appear to be the most suitable position for instillation of steroid nose drops.
类固醇滴鼻剂常用于治疗鼻窦炎和鼻息肉。中鼻道区域在这些病症的病理生理学中至关重要。本研究评估了三种常用滴鼻剂滴入头部位置中哪一种能使该区域获得最高覆盖率。还使用视觉模拟量表对每个位置的不适程度进行了研究。对五名志愿者在以下三种头部位置进行了研究：（i）头部后仰（HB）；（ii）头部前倾并向下（HFD）；以及（iii）仰卧头部后仰（LHB）。将用荧光素染色的倍他米松滴鼻剂滴入每个鼻孔，并通过内窥镜研究其分布情况。中鼻道区域分布在LHB位置最高（55.51%），其次是HFD（31.55%）和HB（6.87%）位置。HB与LHB之间（P = 0.002）以及HB与HFD之间（P = 0.045）的分布比较具有统计学意义。HFD位置最不舒服（平均不适评分为8.8），而HB（2.4）和LHB（2.6）相似。因此，LHB似乎是滴入类固醇滴鼻剂最合适的位置。
