来自卡氏巴豆（Croton cajucara Benth.）的二萜类化合物反式脱氢巴豆素对大鼠的降血糖和降甘油三酯作用。
Blood glucose- and triglyceride-lowering effect of trans-dehydrocrotonin, a diterpene from Croton cajucara Benth., in rats.
作者信息
Silva R M, Santos F A, Rao V S, Maciel M A, Pinto A C
机构信息
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
出版信息
Diabetes Obes Metab. 2001 Dec;3(6):452-6. doi: 10.1046/j.1463-1326.2001.00167.x.
AIM
The objective of this study was to assess in rats the antidiabetic effects (i.e. reduction of hyperglycaemia and hypertriglyceridaemia) of trans-dehydrocrotonin (t-DCTN), a bioactive diterpene isolated from the popular medicinal plant Croton cajucara.
METHODS
Hyperglycaemia was induced by intraperitoneal injection of streptozotocin (STZ) and hypertriglyceridaemia by oral administration of ethanol in rats. The blood glucose levels were measured by the glucose oxidase method using commercially available enzyme kits.
RESULTS
Treating rats with t-DCTN (50 mg/kg) significantly reduced STZ-induced increases in blood glucose levels as well as ethanol-induced increases in blood triglycerides.
CONCLUSION
The results suggest that t-DCTN has an antidiabetic potential that warrants further research on its mechanism and clinical significance.
目的
本研究的目的是在大鼠中评估反式脱氢巴豆素（t-DCTN）的抗糖尿病作用（即降低高血糖和高甘油三酯血症），t-DCTN是从常见药用植物卡氏巴豆中分离出的一种生物活性二萜。
方法
通过腹腔注射链脲佐菌素（STZ）诱导大鼠高血糖，通过口服乙醇诱导大鼠高甘油三酯血症。使用市售酶试剂盒通过葡萄糖氧化酶法测量血糖水平。
结果
用t-DCTN（50mg/kg）治疗大鼠可显著降低STZ诱导的血糖水平升高以及乙醇诱导的血液甘油三酯升高。
结论
结果表明t-DCTN具有抗糖尿病潜力，值得对其作用机制和临床意义进行进一步研究。
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