Wigand R
J Med Virol. 1979;4(1):59-65. doi: 10.1002/jmv.1890040108.
The inhibition of adenovirus multiplication by adenine arabinoside was determined by yield reduction in one-step multiplication cycle. Inhibition was greatly enhanced by an adenosine deaminase inhibitor (2-deoxycoformycin) in concentrations down to 10 ng/ml. Adenovirus types from four subgroups showed similar results. However, the enhancing effect of adenosine deaminase inhibitor was great in HeLa cells, moderate in human fibroblasts, and negligible in Vero cells. This difference could be explained by different concentrations of adenosine deaminase found in cell homogenates.
通过一步增殖周期中的产量降低来测定阿糖腺苷对腺病毒增殖的抑制作用。腺苷脱氨酶抑制剂（2-脱氧助间型霉素）在低至10 ng/ml的浓度下可大大增强抑制作用。来自四个亚组的腺病毒类型显示出相似的结果。然而，腺苷脱氨酶抑制剂的增强作用在HeLa细胞中很大，在人成纤维细胞中中等，而在Vero细胞中可忽略不计。这种差异可以通过细胞匀浆中发现的不同浓度的腺苷脱氨酶来解释。
