Garwood Susan, Reeder Martin, Mackenzie Ian Z, Guillebaud John
Nuffield Department of Anaesthesia Oxford University, UK.
Am J Obstet Gynecol. 2002 Mar;186(3):383-8. doi: 10.1067/mob.2002.121079.
The purpose of this study was to determine whether lidocaine that is instilled onto the Fallopian tubes reduces pain scores in awake patients who undergo laparoscopic sterilization with Filshie clips.
This was a prospective, randomized, placebo-controlled, double-blinded, clinical trial study that was approved by our institutional review board.
Pain scores (visual analogue scales) were lower in the lidocaine group (n = 12 patients) than in the placebo group (n = 12 patients) at clip application (6 vs 71 mm; P <.0001) and after 15 minutes after operation (15.5 vs 44.5 mm; P <.005). No significant differences occurred at 1-hour after operation or discharge, but more rescue analgesia was required in the placebo group ( P <.05), with more side effects ( P <.05). In a separate group of 20 women, serum lidocaine levels were measured (maximum level, 16.0 micromol/L). Holter monitoring of these patients revealed no significant arrhythmias.
One percent lidocaine that is instilled onto the Fallopian tubes reduces pain scores in awake patients who undergo laparoscopic sterilization with Filshie clips.
本研究旨在确定向输卵管内注入利多卡因是否能降低使用Filshie夹进行腹腔镜绝育术的清醒患者的疼痛评分。
这是一项前瞻性、随机、安慰剂对照、双盲临床试验研究，已获得我们机构审查委员会的批准。
在夹闭时（6对71毫米；P<.0001）以及术后15分钟（15.5对44.5毫米；P<.005），利多卡因组（n = 12例患者）的疼痛评分（视觉模拟量表）低于安慰剂组（n = 12例患者）。术后1小时或出院时未出现显著差异，但安慰剂组需要更多的解救镇痛（P<.05），且副作用更多（P<.05）。在另一组20名女性中，测量了血清利多卡因水平（最高水平为16.0微摩尔/升）。对这些患者进行动态心电图监测未发现显著心律失常。
向输卵管内注入1%的利多卡因可降低使用Filshie夹进行腹腔镜绝育术的清醒患者的疼痛评分。
