Lima M, Coutinho J, Bernardo L, dos Anjos Teixeira M, Casais C, Canelhas A, Queirós L, Orfão A, Justiça B
Department of Clinical Hematology, Hospital Geral de Santo António, Rua D Manuel II, s/n, 4099-001 Porto, Portugal.
Ann Hematol. 2002 Mar;81(3):174-7. doi: 10.1007/s00277-001-0422-7. Epub 2002 Jan 31.
Transformation of chronic myeloid leukemia (CML) often results in acute myeloblastic or, less frequently, in precursor B-cell acute lymphoblastic leukemia (ALL). T-cell blast crisis is rare. Hypercalcemia has also been described as a rare complication of CML, but this usually occurs as a terminal event. Here we report a case of a 35-year-old woman who developed a CD4(+)/CD8(+) T-cell ALL 2 years after the diagnosis of a typical Ph(+) CML. Polymyositis and polyarthritis preceded by 4 months, and symptomatic hypercalcemia occurred just before blastic transformation, probably representing paraneoplastic manifestations of the disease.
慢性髓性白血病（CML）的转化通常会导致急性髓细胞性白血病，或者较少见地，导致前体B细胞急性淋巴细胞白血病（ALL）。T细胞急变期很少见。高钙血症也被描述为CML的一种罕见并发症，但这通常发生在终末期。在此，我们报告一例35岁女性病例，该患者在诊断为典型的Ph(+) CML两年后发生了CD4(+)/CD8(+) T细胞ALL。多肌炎和多关节炎先出现4个月，在急变期前出现了有症状的高钙血症，这可能代表了该疾病的副肿瘤表现。
