Hoffmann W, Latza U, Ahrens W, Greiser K H, Kroke A, Nieters A, Schulze M B, Steiner M, Terschüren C, Wjst M
Bremer Institut für Präventonsforschung und Sozialmedizin, Linzer, Strasse, Bremen.
Gesundheitswesen. 2002 Feb;64(2):99-107. doi: 10.1055/s-2002-20274.
The inclusion of biomarkers in epidemiological research provides new possibilities for exposure assessment and the study of early structural or functional changes and pre-clinical stages of diseases. At the same time issues of validity, reliability, and quality control as well as logistics require special attention. Usually epidemiological studies become more expensive with regard to time and cost. Interdisciplinary collaboration between epidemiology, basic research, and laboratory research is crucial. A prerequisite for this collaboration are agreements on definitions, methods and procedures. The definition of "biomarker" and a description of previous uses of biomarkers in epidemiological studies are presented in the first part of this paper. The second part addresses genetic markers and markers of individual sensitivity and susceptibility. We will end with a discussion about the possible future of biomarkers in epidemiology.
将生物标志物纳入流行病学研究为暴露评估以及疾病早期结构或功能变化和临床前阶段的研究提供了新的可能性。与此同时，有效性、可靠性、质量控制以及后勤保障等问题需要特别关注。通常，流行病学研究在时间和成本方面会变得更加昂贵。流行病学、基础研究和实验室研究之间的跨学科合作至关重要。这种合作的一个先决条件是就定义、方法和程序达成一致。本文第一部分介绍了“生物标志物”的定义以及流行病学研究中生物标志物的先前使用情况。第二部分讨论了遗传标志物以及个体敏感性和易感性的标志物。我们将以关于生物标志物在流行病学中可能的未来的讨论作为结尾。
