Krause W, Hamm K, Weissmüller J
Andrologia. 1975;7(2):109-16.
Immature male rats receive orally DDVP 20 mg/kg on the 4th and 5th resp. 10 mg/kg on the 4th to the 24th day of life or malathione 40 resp. 20 mg/kg. At defined days the testes are examined histologically. The body weight does not change. The testis weight, tubular diameter, number of Sertoli cells, and of A-spermatogonia per tubular cross section as well as the number of Leydig cells is diminished. Malathione produced more severe alterations, they disappear, however, until the 50th day of life. Refering to the metabolic mechanisms of both the phosphatic esters a local lack of testosterone causing the disturbances is discussed.
未成熟雄性大鼠在出生后第4天和第5天分别口服20毫克/千克敌敌畏，或在出生后第4天至第24天分别口服10毫克/千克敌敌畏，或40毫克/千克（相应地为20毫克/千克）马拉硫磷。在特定日期对睾丸进行组织学检查。体重没有变化。睾丸重量、曲细精管直径、每个曲细精管横切面的支持细胞数量、A型精原细胞数量以及间质细胞数量均减少。马拉硫磷造成的改变更严重，但这些改变在出生后第50天之前消失。关于这两种磷酸酯的代谢机制，讨论了局部睾酮缺乏导致这些干扰的情况。
