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Damage to spermatogenesis in juvenile rat treated with DDVP and malathion.

作者信息

Krause W, Hamm K, Weissmüller J

出版信息

Bull Environ Contam Toxicol. 1976 Apr;15(4):458-62. doi: 10.1007/BF01685072.

DOI:10.1007/BF01685072
PMID:1260153
Abstract

Juvenile male rats received either 20 mg DDVP or 40 mg malathion/kg on the 4th and 5th day of life, and either 10 mg DDVP or 20 mg/kg malathion daily from the 4th to the 23rd day of life. The histological examination of the testes showed slight reductions of the spermatogentic cells and Leydig cells. Therefore, it is assumed that testosterone synthesis is reduced, followed by damage to spermatogentic cells. All disturbances return by normal by the 50th day of life.

摘要

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本文引用的文献

1
Definition of the stages of the cycle of the seminiferous epithelium in the rat.大鼠生精上皮周期各阶段的定义。
Ann N Y Acad Sci. 1952 Nov 20;55(4):548-73. doi: 10.1111/j.1749-6632.1952.tb26576.x.
2
[Effect of "cyclophosphamide" and "procarbacine" on the seminiferous epithelium in the rat].
Beitr Pathol Anat. 1968;137(4):452-78.
3
Alkylation of DNA by dichlorvos.
Naturwissenschaften. 1970 Aug;57(8):393-4. doi: 10.1007/BF00599981.
4
Hormonal control of mammalian spermatogenesis.
哺乳动物精子发生的激素调控。
Physiol Rev. 1971 Jan;51(1):1-22. doi: 10.1152/physrev.1971.51.1.1.
5
Alterations of the seminiferous epithelium and the Leydig cells of the mouse testis after the application of dichlorvos (DDVP).
Bull Environ Contam Toxicol. 1974 May;11(5):429-33. doi: 10.1007/BF01685299.
6
The effect of DDT on spermatogenesis of the juvenile rat.
Bull Environ Contam Toxicol. 1975 Aug;14(2):171-9. doi: 10.1007/BF01701310.