Lamont E B, Vokes E E
Section of Hematology-Oncology, Cancer Research Center, University of Chicago, IL 60637, USA.
Lancet Oncol. 2001 May;2(5):261-9. doi: 10.1016/S1470-2045(00)00320-X.
Previously reserved for palliation, chemotherapy is now also a central component of several curative approaches to the management of patients with advanced-stage head and neck cancer. Here we review the results of both induction chemotherapy and chemoradiotherapy trials in patients with curable disease, and chemotherapy trials in patients with recurrent and metastatic disease, and we highlight current areas of investigation. Compared with traditional treatment modalities, chemotherapy given on induction schedules to patients with advanced laryngeal cancer allows greater organ preservation without compromise to survival; when given concomitantly with radiotherapy to patients with resectable or unresectable advanced disease, chemotherapy again improves survival.
化疗以前仅用于姑息治疗，现在也是晚期头颈癌患者几种治愈性治疗方法的核心组成部分。在此，我们回顾了可治愈疾病患者的诱导化疗和放化疗试验结果，以及复发和转移性疾病患者的化疗试验结果，并突出了当前的研究领域。与传统治疗方式相比，对晚期喉癌患者进行诱导化疗可在不影响生存率的情况下更好地保留器官；当与放疗同时用于可切除或不可切除的晚期疾病患者时，化疗同样可提高生存率。
