Pfister D G, Shaha A R, Harrison L B
Department of Medicine, Division of Solid Tumor Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Surg Oncol Clin N Am. 1997 Oct;6(4):749-68.
Historically, the application of chemotherapy in patients with squamous cell head and neck cancer had been limited to the palliative setting; however, the role of chemotherapy in the definitive management of these tumors has undergone great evolution during the last 5 to 10 years. Available randomized data currently support a role for chemotherapy as part of combined modality, curative treatment strategies in the management of patients with unresectable disease, advanced nasopharynx cancer, and as part of a larynx preservation approach in patients with advanced larynx or hypopharynx cancer requiring total laryngectomy. Chemoprevention as a strategy to prevent second primary tumors also shows great promise.
从历史上看，化疗在头颈部鳞状细胞癌患者中的应用一直局限于姑息治疗；然而，在过去5至10年中，化疗在这些肿瘤的确定性治疗中的作用发生了巨大演变。目前可用的随机数据支持化疗作为联合治疗模式的一部分，在不可切除疾病、晚期鼻咽癌患者的根治性治疗策略中发挥作用，以及在需要全喉切除术的晚期喉癌或下咽癌患者的喉保留方法中发挥作用。化学预防作为预防第二原发肿瘤的策略也显示出巨大的前景。
