Pharmacogenetics and cancer therapy.
作者信息
Relling M V, Dervieux T
机构信息
Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
出版信息
Nat Rev Cancer. 2001 Nov;1(2):99-108. doi: 10.1038/35101056.
DOI:10.1038/35101056
PMID:11905809
Abstract
Pharmacogenetics is the study of how genetic variations affect drug response. These variations can affect a patient's response to cancer drugs, for which there is usually a fine line between a dosage that has a therapeutic effect and one that produces toxicity. Gaining better insight into the genetic elements of both the patient and the tumour that affect drug efficacy will eventually allow for individualized dosage determination and fewer adverse effects.
摘要
Zotero 插件