Wang Z H, Liao Y H, Fu M
Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical University, Wuhan, China.
Autoimmunity. 2001;34(4):241-5. doi: 10.3109/08916930109014693.
The aim of this study was to examine the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=29) and a negative group (Non-HVM group, n=74) according to the laboratory findings regarding their type of hepatitis virus. The study parameters included UCG, ECG, biochemical findings and screening of autoantibodies against beta1-adrenoceptor. It was shown that the positive rate of the hepatitis virus was 28.16% (29/103) in patients with viral myocarditis. The severity of myocardial or liver injuries and the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with viral myocarditis were more pronounced, before treatment, in the HVM group than in the Non-HVM group. The positive rates of the antibodies against the hepatitis virus and the autoantibodies against beta1-adrenoceptors were highly consistent in patients with HVM (p<0.05). In conclusion, the frequency of occurrence of the autoantibodies against beta1-adrenoceptors may be one important marker of HVM and, thus, possibly involved in the pathogenesis of the HVM.
本研究旨在检测肝炎病毒相关性心肌炎（HVM）患者中抗β1 -肾上腺素能受体自身抗体的发生率及其与临床特征的可能相关性。根据肝炎病毒类型的实验室检查结果，将103例病毒性心肌炎患者分为阳性组（HVM组，n = 29）和阴性组（非HVM组，n = 74）。研究参数包括超声心动图（UCG）、心电图（ECG）、生化检查结果以及抗β1 -肾上腺素能受体自身抗体的筛查。结果显示，病毒性心肌炎患者中肝炎病毒的阳性率为28.16%（29/103）。治疗前，HVM组病毒性心肌炎患者心肌或肝脏损伤的严重程度以及抗β1 -肾上腺素能受体自身抗体的发生率比非HVM组更明显。HVM患者中抗肝炎病毒抗体和抗β1 -肾上腺素能受体自身抗体的阳性率高度一致（p<0.05）。总之，抗β1 -肾上腺素能受体自身抗体的发生率可能是HVM的一个重要标志物，因此可能参与了HVM的发病机制。
