Ajith T A, Janardhanan K K
Amala Cancer Research Centre, Amala Nagar, Thrissur, India.
Indian J Exp Biol. 2001 Nov;39(11):1166-9.
The methanolic extract of a macrofungus, P. rimosus possessed significant in vitro superoxide anion, hydroxyl radical and nitric oxide scavenging and lipid peroxidation inhibiting activities. The anti-inflammatory activity of the extract was evaluated in carrageenan and dextran induced acute and formalin induced chronic inflammatory models in mice. The extract showed remarkable anti-inflammatory activity in both models, comparable to the standard reference drug diclofenac. The results suggest that the anti-inflammatory activity of the methanol extract of P. rimosus is possibly attributed to it's free radical scavenging properties. The findings also reveal the potential therapeutic value of P.rimosus extract as an antiinflammatory agent.
一种大型真菌——粗皮侧耳的甲醇提取物具有显著的体外超氧阴离子、羟基自由基清除能力，以及一氧化氮清除和脂质过氧化抑制活性。在角叉菜胶和葡聚糖诱导的小鼠急性炎症模型以及福尔马林诱导的慢性炎症模型中评估了该提取物的抗炎活性。在这两种模型中，该提取物均表现出显著的抗炎活性，与标准参考药物双氯芬酸相当。结果表明，粗皮侧耳甲醇提取物的抗炎活性可能归因于其自由基清除特性。这些发现还揭示了粗皮侧耳提取物作为抗炎剂的潜在治疗价值。
